Cheap Blood Pressure Drug Cures Diabetes In Mice, Human Trials Announ

Funding has been secured for a clinical trial of a drug that not only prevents mice from getting type I diabetes, but actually reverses the condition if it has already taken hold.

Verapamil is a calcium channel blocker used to treat hypertension, irregular heartbeats and some sorts of headaches. It has been approved for some of these purposes for over 30 years.
Verapamil has dangerous interactions with some other drugs. However, while side-effects such as nausea and swollen feet may be unpleasant, the dangers are seldom life threatening, and generally a better alternative to having diabetes. Such a history of long-term usage should shorten the clinical trial process and improve the chances of gaining regulatory approval.
The potential application to diabetes arises from the discovery by Dr. Anath Shalev of the University of Alabama, Birmingham (UAB) that verapamil lowers the level of the protein TXNIP in pancreatic beta cells.
Back in 2002, Shalev, then at the University of Wisconsin-Madison, began a search to find the gene that responded most strongly in the pancreas to excessive glucose levels. This turned out to be the TXNIP gene. Moreover, TXNIP’s full name is thioredoxin-interacting protein; high levels of thioredoxin have been shown to keep the pancreas’ insulin-producing islet beta cells alive.
Shalev began to suspect TXNIP suppression might be the key to fighting diabetes, and subsequent tests in rats, mice and islets isolated from humans have lent weight to her theory.
“We have previously shown that verapamil can prevent diabetes and even reverse the disease in mouse models and reduce TXNIP in human islet beta cells, suggesting that it may have beneficial effects in humans as well,” Shalev said, announcing plans for the clinical trials.
Most recently, Shalev revealed that TXNIP can stimulate its own expression. “These findings support the notion,” Shaleve wrote, “that TXNIP levels rise over time, not only as a result of elevated blood glucose levels and/or endoplasmic reticulum stress, but also as part of a vicious cycle by which increased TXNIP levels lead to more TXNIP expression and thereby amplify the associated detrimental effects on beta-cell biology including oxidative stress, inflammation, and ultimately beta-cell death and disease progression.”
 http://www.jewsnews.co.il/2014/11/12/cheap-blood-pressure-drug-cures-diabetes-in-mice-human-trials-announced/